Literature summary for 3.1.7.6 extracted from

Meigs, T.E.; Simoni, R.D.
Farnesol as a regulator of HMG-CoA reductase degradation: characterization and role of farnesyl pyrophosphatase (1997), Arch. Biochem. Biophys., 345, 1-9.

Search for more literature for 3.1.7.6

Protein Variants

Protein Variants	Comment	Organism
up	enzyme activity increases under conditions of increased metabolic flow through the isoprenoid pathway	Cricetulus griseus

Inhibitors

Inhibitors	Comment	Organism	Structure
(2E,6E)-farnesyl diphosphate	competitive	Cricetulus griseus
farnesyl diphosphate	0.25 mM, 80% inhibition	Cricetulus griseus
farnesyl monophosphate	0.07 mM, 35% inhibition	Cricetulus griseus
geranylgeranyl diphosphate	0.05 mM, 60% inhibition	Cricetulus griseus
NaF	100 mM, about 70% inhibition	Cricetulus griseus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.015	-	(2E,6E)-farnesyl diphosphate	pH 5.5, 37°C	Cricetulus griseus

Organism

Organism	UniProt	Comment	Textmining
Cricetulus griseus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(2E,6E)-farnesyl diphosphate + H2O	-	Cricetulus griseus	(2E,6E)-farnesol + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
farnesyl pyrophosphatase	-	Cricetulus griseus
FPPase	-	Cricetulus griseus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Cricetulus griseus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
5.5	-	assay at	Cricetulus griseus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.37	-	(2E,6E)-farnesyl diphosphate	pH 5.5, 37°C	Cricetulus griseus

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Release 2023.1 (January 2023)