Literature summary for 3.1.7.11 extracted from

Jiang, G.Z.; Yao, M.D.; Wang, Y.; Zhou, L.; Song, T.Q.; Liu, H.; Xiao, W.H.; Yuan, Y.J.
Manipulation of GES and ERG20 for geraniol overproduction in Saccharomyces cerevisiae (2017), Metab. Eng., 41, 57-66 .

Search for more literature for 3.1.7.11

Application

Application	Comment	Organism
synthesis	synthesis of geraniol by expression of GES truncated at residue S43 in Saccharomyces cerevisiae. Coexpression of the reverse fusion of farnesyl diphosphate synthase Erg20 mutant F96W-N127W and truncated GES and another copy of farnesyl diphosphate synthase Erg20 mutant F96W-N127W promotes the geraniol titer to 523.96 mg/l at shakes flask level. A highest reported titer of 1.68 g/l geraniol in eukaryote cells is achieved in 2.0 l fed-batch fermentation under carbon restriction strategy	Catharanthus roseus

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Saccharomyces cerevisiae	Catharanthus roseus

Protein Variants

Protein Variants	Comment	Organism
D501A	30% of wild-type activity	Catharanthus roseus
additional information	N-terminal truncation at residues S14, L28, S43and S52 all lead to an increase on geraniol production	Catharanthus roseus
Y436A	12% of wild-type activity	Catharanthus roseus
Y436A/D501A	10% of wild-type activity	Catharanthus roseus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
plastid	-	Catharanthus roseus	9536	-

Organism

Organism	UniProt	Comment	Textmining
Catharanthus roseus	J9PZR5	-	-

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Release 2023.1 (January 2023)