Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dexamethasone | inhibits STS activity and expression in undifferentiated cells, the glucocorticoid antagonist RU486 reverses dexamethasone inhibition of STS | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P08842 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MG-63 cell | - |
Homo sapiens | - |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | STS activity and gene expression are decreased during differentiation in cells treated with osteogenic supplement containing dexamethasone. The NFkappaB activators lipopolysaccharide and phorbol myristate acetate increase STS expression in undifferentiated and differentiated MG-63 cells, while the NFkappaB inhibitor BAY-11-7082 partially blocks these responses | additional information |