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Literature summary for 3.1.6.2 extracted from

  • Phan, C.M.; Liu, Y.; Kim, B.M.; Mostafa, Y.; Taylor, S.D.
    Inhibition of steroid sulfatase with 4-substituted estrone and estradiol derivatives (2011), Bioorg. Med. Chem., 19, 5999-6005.
    View publication on PubMed
Search for more literature for 3.1.6.2

Inhibitors

Inhibitors Comment Organism Structure
2-formyl-17alpha-benzyl-17beta-hydroxyestra-1,3,5(10)-triene time- and concentration-dependent inhibitor, shows more or less pseudo-first order behavior at all concentrations Homo sapiens
4-fluoro-17alpha-benzyl-17beta-hydroxyestra-1,3,5(10)-triene linear mixed-type inhibition, compound is capable of binding at sites both within and outside the active site Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylumbelliferyl sulfate + H2O
-
 Homo sapiens 4-methylumbelliferol + sulfate
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000085
-
 2-formyl-17alpha-benzyl-17beta-hydroxyestra-1,3,5(10)-triene pH 7.0, temperature not specified in the publication Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00004
-
 pH 7.0, temperature not specified in the publication Homo sapiens 4-fluoro-17alpha-benzyl-17beta-hydroxyestra-1,3,5(10)-triene