Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(17beta)-17-(4-tert-butylbenzyl)estra-1(10),2,4-triene-3,17-diol | estradiol phenolic reversible inhibitor as reference, possible additional breast cancer therapy, no inhibition at 0.01 microM, at 0.1 microM 39% inhibition, at 1 microM 62% inhibition | Homo sapiens | |
(17beta)-17-benzylestra-1(10),2,4-triene-3,17-diol | estradiol phenolic reversible inhibitor as reference, possible additional breast cancer therapy, no inhibition at 0.01 microM, at 0.1 microM 15% inhibition, at 1 microM 48% inhibition | Homo sapiens | |
(17beta,17'beta)-17,17'-(2E)-but-2-ene-1,4-diylbisestra-1(10),2,4-triene-3,17-diol | reversible non-competitive or mixed inhibition, estradiol dimer with C17-C17 bond, possible additional breast cancer therapy, no inhibition at 0.01 microM, at 0.1 microM 42% inhibition, at 1 microM 56% inhibition | Homo sapiens | |
(17beta,17'beta)-17,17'-butane-1,4-diylbisestra-1(10),2,4-triene-3,17-diol | reversible non-competitive or mixed inhibition, estradiol dimer with C17-C17 bond, possible additional breast cancer therapy, no inhibition at 0.01 microM, at 0.1 microM 30% inhibition, at 1 microM 54% inhibition | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dehydroepiandrosterone sulfate + H2O | Homo sapiens | - |
dehydroepiandrosterone + sulfate | subsequent conversion to estradiol with 3beta-hydroxysteroid dehydrogenase, aromatase and 17beta-hydroxysteroid dehydrogenase | ? | |
estrone sulfate + H2O | Homo sapiens | - |
estrone + sulfate | subsequent conversion to estradiol with 17beta-hydroxysteroid dehydrogenase | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | human embryonic kidney cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dehydroepiandrosterone sulfate + H2O | - |
Homo sapiens | dehydroepiandrosterone + sulfate | subsequent conversion to estradiol with 3beta-hydroxysteroid dehydrogenase, aromatase and 17beta-hydroxysteroid dehydrogenase | ? | |
estrone sulfate + H2O | - |
Homo sapiens | estrone + sulfate | subsequent conversion to estradiol with 17beta-hydroxysteroid dehydrogenase | ? |
Synonyms | Comment | Organism |
---|---|---|
steroid sulfatase | - |
Homo sapiens |
STS | - |
Homo sapiens |