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Literature summary for 3.1.6.2 extracted from

  • Clemens, J.W.; Kabler, H.L.; Sarap, J.L.; Beyer, A.R.; Li, P.K.; Selcer, K.W.
    Steroid sulfatase activity in the rat ovary, cultured granulosa cells, and a granulosa cell line (2000), J. Steroid Biochem. Mol. Biol., 75, 245-252.
    View publication on PubMed
Search for more literature for 3.1.6.2

Inhibitors

Inhibitors Comment Organism Structure
estrone-3-O-sulfamate highly potent, specific STS inhibitor, complete inhibition at 0.001 mM Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.072
-
 Estrone sulfate pH 7.5, 37°C, POGS-5 microsomes Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome from POGS-5 cell line Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus ovarian estrogen synthesis, the relative contribution of STS activity to ovarian steroidogenesis is unclear but may have important physiological and pathophysiological implications ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 immature female Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
granulosa cell primary cultures of granulosa cells matured in vitro with follicle-stimulating hormone and testosterone Rattus norvegicus
-
additional information no STS activity in the immortalized rat granulosa cell line POGRS-1 Rattus norvegicus
-
ovary crude homogenate, from immature female Sprague-Dawley rats treated with gonadotropin in vivo Rattus norvegicus
-
POGS-5 cell immortalized rat granulosa cell line Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dehydroepiandrosterone sulfate + H2O
-
 Rattus norvegicus dehydroepiandrosterone + sulfate
-
 ?
estrone sulfate + H2O
-
 Rattus norvegicus estrone + sulfate
-
 ?
additional information ovarian estrogen synthesis, the relative contribution of STS activity to ovarian steroidogenesis is unclear but may have important physiological and pathophysiological implications Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
STS
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Rattus norvegicus