Any feedback?
Literature summary for 3.1.6.2 extracted from
- Characterization of point mutations in patients with X-linked ichthyosis. Effects on the structure and function of the steroid sulfatase protein (1997), J. Biol. Chem., 272, 20756-20763.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | point mutations in 3 patients | Homo sapiens |
| medicine | deficiency in X-linked placental insufficiency and X-linked ichthyosis | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in mouse A9 cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C446Y | patient with X-linked ichthyosis | Homo sapiens |
| H444R | patient with X-linked ichthyosis | Homo sapiens |
| R419S | patient with X-linked ichthyosis | Homo sapiens |
| S341L | patient with X-linked ichthyosis | Homo sapiens |
| W372P | patient with X-linked ichthyosis | Homo sapiens |
| W372R | patient with X-linked ichthyosis | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 62000 | - |
amino acid analysis | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| steroid sulfates + H2O | Homo sapiens | also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site | steroid + sulfate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | 4 sites for possible glycosylation, only 2 sites used | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| estrone sulfate + H2O | - |
Homo sapiens | estrone + sulfate | - |
? | |
| steroid sulfates + H2O | also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site | Homo sapiens | steroid + sulfate | - |
? | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
