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Literature summary for 3.1.6.2 extracted from
- Distribution and characterization of neurosteroid sulfatase from the bovine brain (1997), J. Steroid Biochem. Mol. Biol., 62, 315-320.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| p-Nitrophenyl sulfate | noncompetitive inhibitor, dehydroepiandrosterone 3-sulfate as substrate | Bos taurus |  |
| pregnenolone 3-sulfate | competitive inhibitor, dehydroepiandrosterone 3-sulfate as substrate | Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.113 | - |
dehydroepiandrosterone 3-sulfate | - |
Bos taurus | |
| 1600 | - |
p-Nitrophenyl sulfate | - |
Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Bos taurus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| steroid sulfates + H2O | Bos taurus | also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site | steroid + sulfate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | midbrain, hypothalamus | Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dehydroepiandrosterone 3-sulfate + H2O | - |
Bos taurus | dehydroepiandrosterone + sulfate | - |
? | |
| p-nitrophenyl-sulfate + H2O | - |
Bos taurus | p-nitrophenol + sulfate | - |
? | |
| steroid sulfates + H2O | also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site | Bos taurus | steroid + sulfate | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 50 | - |
- |
Bos taurus |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | 60 | - |
Bos taurus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 60 | - |
30% loss of activity | Bos taurus |
| 70 | - |
complete loss of activity | Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 4 | - |
and pH 7.4, 2 optima | Bos taurus |
| 7.4 | - |
and pH 4.0, 2 optima | Bos taurus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4 | 8 | - |
Bos taurus |
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Release 2023.1 (January 2023)
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