Activating Compound | Comment | Organism | Structure |
---|---|---|---|
bovine serum albumin | activation | Homo sapiens | |
bovine serum albumin | over pH-range 2.7-5.7, maximal activation at 1 mg/ml and pH 3.3, glucuronic acid 2-sulfate-2,5-anhydro-D-mannitol 6-sulfate as substrate | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | above pH 4.2, activation over pH-range 3-4.2, glucuronic acid 2-sulfate-2,5-anhydro-D-mannitol 6-sulfate as substrate | Homo sapiens | |
EDTA | glucuronic acid 2-sulfate-2,5-anhydro-D-mannitol 6-sulfate as substrate | Homo sapiens | |
NaCl | at pH 3, glucuronic acid 2-sulfate-2,5-anhydro-D-mannitol 6-sulfate as substrate; stimulates between pH 4.2-4.8 | Homo sapiens | |
NaH2PO4 | glucuronic acid 2-sulfate-2,5-anhydro-D-mannitol 6-sulfate as substrate | Homo sapiens | |
SO42- | glucuronic acid 2-sulfate-2,5-anhydro-D-mannitol 6-sulfate as substrate; product inhibition | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | activation | Homo sapiens | |
Cu2+ | pH-dependent: over pH-range 3-4.2, inhibits at higher pH, glucuronic acid 2-sulfate-2,5-anhydro-D-mannitol 6-sulfate as substrate | Homo sapiens | |
NaCl | stimulation, over pH-range 4.2-4.8, glucuronic acid 2-sulfate-2,5-anhydro-D-mannitol 6-sulfate as substrate, inhibits at pH 3 | Homo sapiens | |
Zn2+ | activation | Homo sapiens | |
Zn2+ | over pH-range 3-4.8 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
skin fibroblast | cell culture | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucuronic acid 2-sulfate-2,5-anhydro-D-mannitol 6-sulfate + H2O | i.e. O-beta-glucuronic acid 2-sulfate-1,4-O-(2,5)-anhydromannitol 6-sulfate | Homo sapiens | D-glucuronic acid 2,5-anhydro-D-mannitol 6-sulfate + SO42- | - |
? | |
D-glucuronic acid 2-sulfate-2,5-anhydro-D-mannitol 6-sulfate + H2O | i.e. GSMS | Homo sapiens | D-glucuronic acid 2,5-anhydro-D-mannitol 6-sulfate + SO42- | - |
? | |
D-glucuronic acid 2-sulfate-2,5-anhydro-D-talitol 6-sulfate + H2O | i.e. O-beta-glucuronic acid 2-sulfate-1,4-O-(2,5)-anhydrotalitol 6-sulfate | Homo sapiens | D-glucuronic acid 2,5-anhydro-D-talitol 6-sulfate + SO42- | - |
? | |
D-glucuronic acid 2-sulfate-2,5-anhydro-D-talitol 6-sulfate + H2O | i.e. GSTS | Homo sapiens | D-glucuronic acid 2,5-anhydro-D-talitol 6-sulfate + SO42- | - |
? | |
additional information | no hydrolysis of iduronate 2-sulfate residues | Homo sapiens | ? | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
additional information | - |
the pH/activity profile depends on buffer composition and ionic strength, particularly at lower pH-values | Homo sapiens |
2.7 | - |
20 mM sodium formate buffer, glucuronic acid 2-sulfate-2,5-anhydro-D-talitol 6-sulfate as substrate | Homo sapiens |
3 | - |
glucuronic acid 2-sulfate-2,5-anhydro-D-mannitol 6-sulfate as substrate | Homo sapiens |
3 | - |
4-20 mM sodium formate or 20-60 mM sodium acetate buffer | Homo sapiens |
3.3 | - |
60 mM sodium formate or 60 mM glycine/HCl buffer, glucuronic acid 2-sulfate-2,5-anhydro-D-mannitol 6-sulfate as substrate | Homo sapiens |