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Literature summary for 3.1.6.14 extracted from

  • Basner, R.; Kresse, H.; von Figura, K.
    N-Acetylglucosamine-6-sulfate sulfatase from human urine (1979), J. Biol. Chem., 254, 1151-1158.
    View publication on PubMed
Search for more literature for 3.1.6.14

Inhibitors

Inhibitors Comment Organism Structure
bovine serum albumin
-
 Homo sapiens
CN-
-
 Homo sapiens
Hg2+
-
 Homo sapiens
PO43-
-
 Homo sapiens
S2O32-
-
 Homo sapiens
SO32-
-
 Homo sapiens
SO42-
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.15
-
 trisaccharide with an N-acetylglucosamine 6-sulfate residue
-
 Homo sapiens
7.7
-
 glucose 6-sulfate
-
 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
97000
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetyl-D-glucosamine 6-sulfate units + H2O Homo sapiens in oligo-and monosaccharides derived from heparan sulfate and keratan sulfate N-acetyl-D-glucosamine units + sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-
skin fibroblast in culture Homo sapiens
-
spleen
-
 Homo sapiens
-
telencephalon
-
 Homo sapiens
-
urine
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glucose 6-sulfate + H2O
-
 Homo sapiens glucose + sulfate
-
 ?
N-acetyl-D-glucosamine 6-sulfate + H2O higher activity in liver compared to trisaccharides Homo sapiens N-acetyl-D-glucosamine + sulfate
-
 ?
N-acetyl-D-glucosamine 6-sulfate units + H2O catalyzes hydrolysis of sulfate from internal N-acetylglucosamine 6-sulfate at a lower rate Homo sapiens N-acetyl-D-glucosamine units + sulfate
-
 ?
N-acetyl-D-glucosamine 6-sulfate units + H2O in substrates bearing a N-acetylglucosamine 6-sulfate residue at its nonreducing terminus derived from heparan sulfate and keratan sulfate Homo sapiens N-acetyl-D-glucosamine units + sulfate
-
 ?
N-acetyl-D-glucosamine 6-sulfate units + H2O specific exosulfatase for desulfation of the nonreducing terminal N-acetylglucosamine 6-sulfate residues of heparansulfate Homo sapiens N-acetyl-D-glucosamine units + sulfate
-
 ?
N-acetyl-D-glucosamine 6-sulfate units + H2O has no activity towards heparin, heparansulfate and keratansulfate, increase of activity in monosulfated tetra- or trisaccharides, maximum activity in sulfated monosaccharides Homo sapiens N-acetyl-D-glucosamine units + sulfate
-
 ?
N-acetyl-D-glucosamine 6-sulfate units + H2O in oligo-and monosaccharides derived from heparan sulfate and keratan sulfate Homo sapiens N-acetyl-D-glucosamine units + sulfate
-
 ?
trisaccharide derived from heparansulfate with a N-acetylglucosamine 6-sulfate residue + H2O lower activity in liver compared to monosaccharides Homo sapiens trisaccharide with a N-acetylglucosamine + sulfate
-
 ?
trisaccharide with an N-acetylglucosamine 6-sulfate residue + H2O
-
 Homo sapiens trisaccharide with an N-acetylglucosamine + sulfate
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
70
-
 after 3 min 70% loss of activity Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
 trisaccharide Homo sapiens

pH Stability

pH Stability pH Stability Maximum Comment Organism
5 7.5
-
 Homo sapiens