Literature summary for 3.1.6.13 extracted from

Okuyama, T.; Tanaka, A.; Suzuki, Y.; Ida, H.; Tanaka, T.; Cox, G.; Eto, Y.; Orii, T.
Japan Elaprase Treatment (JET) study: idursulfase enzyme replacement therapy in adult patients with attenuated Hunter syndrome (Mucopolysaccharidosis II, MPS II) (2010), Mol. Genet. Metab., 99, 18-25.

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Application

Application	Comment	Organism
medicine	idursulfase treatment appears to be safe and effective in adult Japanese patients with attenuated Mucopolysaccharidosis II	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
lysosome	-	Homo sapiens	5764	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
iduronate-2-sulfatase	-	Homo sapiens
idursulfase	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	male patients, ages 21-53 years, receiving weekly intravenous infusions of 0.5 mg/kg idursulfase for 12 months, show significant reductions in lysosomal storage and several clinical improvements. Idursulfase is generally well-tolerated. Infusion-related reactions occur in 50% of patients and are mostly mild with transient skin reactions that do not require medical intervention. Two infusion-related reactions are assessed as serious (urticaria and vasovagal syncope)	Homo sapiens

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Release 2023.1 (January 2023)