Inhibitors | Comment | Organism | Structure |
---|---|---|---|
NaCl | - |
Homo sapiens | |
phosphate | - |
Homo sapiens | |
SO42- | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.013 | - |
O-(alpha-L-idopyranosyluronic acid 2-sulfate)-(1-4)-2,5-anhydro-D-mannitol 6-sulfate | form A | Homo sapiens | |
0.015 | - |
O-(alpha-L-idopyranosyluronic acid 2-sulfate)-(1-4)-2,5-anhydro-D-mannitol 6-sulfate | form B | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
80000 | 115000 | form A, gel filtration, SDS-PAGE | Homo sapiens |
81000 | 83000 | form B, gel filtration | Homo sapiens |
83000 | 94000 | form A, sucrose density gradient centrifugation | Homo sapiens |
170000 | 190000 | form B, sucrose density gradient centrifugation | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dermatan sulfate + H2O | Homo sapiens | - |
dermatan + sulfate | - |
? | |
heparan sulfate + H2O | Homo sapiens | - |
dermatan + sulfate | - |
? | |
heparin + H2O | Homo sapiens | - |
desulfated heparin + sulfate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
2 forms: A, B | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | contains sialic acid residues | Homo sapiens |
Purification (Comment) | Organism |
---|---|
partial | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dermatan sulfate + H2O | - |
Homo sapiens | dermatan + sulfate | - |
? | |
heparan sulfate + H2O | - |
Homo sapiens | dermatan + sulfate | - |
? | |
heparin + H2O | - |
Homo sapiens | desulfated heparin + sulfate | - |
? | |
O-(alpha-L-idopyranosyluronic acid 2-sulfate)-(1-4)-2,5-anhydro-D-mannitol 6-sulfate + H2O | - |
Homo sapiens | O-(alpha-L-idopyranosyluronic acid)-(1-4)-2,5-anhydro-D-mannitol 6-sulfate + sulfate | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
50 | - |
stable for 5 min | Homo sapiens |
55 | - |
30 min, 50% loss of activity of form A, 45 min, 50% loss of activity of form B | Homo sapiens |
64 | - |
5 min, 50% loss of activity | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4 | - |
- |
Homo sapiens |