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Literature summary for 3.1.6.12 extracted from
- Dihydrotestosterone inhibits arylsulfatase B and Dickkopf Wnt signaling pathway inhibitor (DKK)-3 leading to enhanced Wnt signaling in prostate epithelium in response to stromal Wnt3A (2019), Prostate, 79, 689-700 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P15848 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| prostate gland | - |
Homo sapiens | - |
| prostate gland cancer cell | compared to normal prostate cells or stroma, in malignant epithelium, expression of ARSB and Dickkopf Wnt Signaling Pathway Inhibitor DKK3 declines, and expression of galactose-6-sulfate-sulfatase and Wnt signaling targets increases | Homo sapiens | - |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | exposure to 5alpha-dihydrotestosterone increases ARSB and DKK3 promoter methylation, resulting in decreased expression | down |
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Release 2023.1 (January 2023)
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