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Literature summary for 3.1.6.12 extracted from
- Arylsulfatase B regulates interaction of chondroitin-4-sulfate and kininogen in renal epithelial cells (2010), Biochim. Biophys. Acta, 1802, 472-477.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | ASB silencing and overexpression are associated with alterations in syndecan-1 and decorin expression in MCF-7 cells and in IL-8 secretion in human bronchial epithelial cells. Silencing or overexpression of ASB in normal rat kidney epithelial cells in tissue culture modified the content of total sulfated glycosaminoglycans, chondroitin 4-sulfate, kininogen, and bradykinin in spent media and cell lysates. When ASB is overexpressed, the cellular kininogen that associated with C4S declines | Homo sapiens |
| additional information | ASB silencing or overexpression, silencing leads to reduced ASB activity, which than leads to increased chondroitin-4-sulfation, increased binding of kininogen, and reduced bradykinin release | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| lysosome | - |
Homo sapiens | 5764 | - |
| lysosome | - |
Rattus norvegicus | 5764 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| chloride | affects the enzyme activity | Homo sapiens |  |
| chloride | affects the enzyme activity | Rattus norvegicus | |
| phosphate | affects the enzyme activity | Homo sapiens | |
| phosphate | affects the enzyme activity | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| chondroitin 4-sulfate + H2O | Rattus norvegicus | - |
chondroitin + sulfate | - |
? | |
| chondroitin sulfate + H2O | Homo sapiens | - |
? | - |
? | |
| chondroitin sulfate + H2O | Rattus norvegicus | - |
? | - |
? | |
| dermatan sulfate + H2O | Homo sapiens | - |
? | - |
? | |
| dermatan sulfate + H2O | Rattus norvegicus | - |
? | - |
? | |
| additional information | Homo sapiens | ARSB removes 4-sulfate groups from the nonreducing end of chondroitin-4-sulfate and dermatan sulfate | ? | - |
? | |
| additional information | Rattus norvegicus | ARSB removes 4-sulfate groups from the nonreducing end of chondroitin-4-sulfate and dermatan sulfate | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| breast | - |
Homo sapiens | - |
| epithelial cell | - |
Rattus norvegicus | - |
| epithelial cell | brochial and renal | Homo sapiens | - |
| epithelial cell | renal | Rattus norvegicus | - |
| kidney | - |
Homo sapiens | - |
| kidney | - |
Rattus norvegicus | - |
| lung | - |
Homo sapiens | - |
| MCF-7 cell | - |
Homo sapiens | - |
| NRK-52E cell | or NRK-E52 cell, renal epithelial cell | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-methylumbelliferyl sulfate + H2O | - |
Rattus norvegicus | ? | - |
? | |
| chondroitin 4-sulfate + H2O | - |
Rattus norvegicus | chondroitin + sulfate | - |
? | |
| chondroitin sulfate + H2O | - |
Homo sapiens | ? | - |
? | |
| chondroitin sulfate + H2O | - |
Rattus norvegicus | ? | - |
? | |
| dermatan sulfate + H2O | - |
Homo sapiens | ? | - |
? | |
| dermatan sulfate + H2O | - |
Rattus norvegicus | ? | - |
? | |
| additional information | ARSB removes 4-sulfate groups from the nonreducing end of chondroitin-4-sulfate and dermatan sulfate | Homo sapiens | ? | - |
? | |
| additional information | ARSB removes 4-sulfate groups from the nonreducing end of chondroitin-4-sulfate and dermatan sulfate | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ARSB | - |
Homo sapiens |
| ARSB | - |
Rattus norvegicus |
| arylsulfatase B | - |
Homo sapiens |
| arylsulfatase B | - |
Rattus norvegicus |
| ASB | - |
Homo sapiens |
| ASB | - |
Rattus norvegicus |
| N-acetylgalactosamine 4-sulfatase | - |
Homo sapiens |
| N-acetylgalactosamine 4-sulfatase | - |
Rattus norvegicus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | arylsulfatase B is associated with the lysosomal storage disease mucopolysaccharidosis VI | Homo sapiens |
| malfunction | silencing or overexpression of ASB in normal rat kidney epithelial cells in tissue culture modifies the content of total sulfated glycosaminoglycans, C4S, kininogen, and bradykinin in spent media and cell lysates. Treatment of the cultured cells with chondroitinase ABC also increases the secretion of bradykinin into the spent media and reduces the C4S-associated kininogen. When ASB is overexpressed, the cellular kininogen that associates with C4S declines, suggesting a vital role for chondroitin-4-sulfation in regulating the kininogen-C4S interaction | Rattus norvegicus |
| physiological function | arylsulfatase B regulates interaction of chondroitin-4-sulfate and kininogen in renal epithelial cells. ASB activity may provide a link between salt responsiveness and the bradykinin-associated mechanism of blood pressure regulation | Homo sapiens |
| physiological function | arylsulfatase B regulates interaction of chondroitin-4-sulfate and kininogen in renal epithelial cells. ASB activity may provide a link between salt responsiveness and the bradykinin-associated mechanism of blood pressure regulation | Rattus norvegicus |
| physiological function | ASB, owing to its effect on chondroitin-4-sulfation, impacts on the kininogen-bradykinin axis and, thereby, may influence blood pressure | Rattus norvegicus |
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