Literature summary for 3.1.6.12 extracted from

Harmatz, P.; Giugliani, R.; Schwartz, I.V.; Guffon, N.; Teles, E.L.; Miranda, M.C.; Wraith, J.E.; Beck, M.; Arash, L.; Scarpa, M.; Ketteridge, D.; Hopwood, J.J.; Plecko, B.; Steiner, R.; Whitley, C.B.; Kaplan, P.; Yu, Z.F.; Swiedler, S.J.; Decker, C.; Decker, C.
Long-term follow-up of endurance and safety outcomes during enzyme replacement therapy for mucopolysaccharidosis VI: Final results of three clinical studies of recombinant human N-acetylgalactosamine 4-sulfatase (2008), Mol. Genet. Metab., 94, 469-475.

Application

Application	Comment	Organism
medicine	mucopolysaccharidosis type VI is a lysosomal storage disease in which deficient activity of the enzyme arylsulfatase B impairs the stepwise degradation of the glycosaminoglycan dermatan sulfate	Homo sapiens

Cloned (Comment)	Organism
expressed in Escherichia coli	Homo sapiens

Localization	Comment	Organism	GeneOntology No.	Textmining
lysosome	-	Homo sapiens	5764	-

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dermatan sulfate + H2O	-	Homo sapiens	dermatan + sulfate	-	?

Synonyms	Comment	Organism
arylsulfatase B	-	Homo sapiens
ASB	-	Homo sapiens
N-acetylgalactosamine 4-sulfatase	-	Homo sapiens

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Release 2023.1 (January 2023)