Literature summary for 3.1.6.12 extracted from

Gorham, S.D.; Cantz, M.
Arylsulphatase B, an exo-sulphatase for chondroitin 4-sulphate tetrasaccharide (1978), Hoppe-Seyler's Z. Physiol. Chem., 359, 1811-1814.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
N-acetyl-D-galactosamine 4-sulfate units + H2O	Homo sapiens	acts also on N-acetylglucosamine 4-sulfate	N-acetyl-D-galactosamine units + sulfate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(2-acetamido-2-deoxy-O-(beta-D-glucuronic acid)-4-O-sulpho-D-galactose)2 + H2O	exo-sulfatase, stepwise degradation of glycosaminoglycans	Homo sapiens	(2-acetamido-2-deoxy-O-(beta-D-glucuronic acid)-D-galactose)2 + sulfate	-	?
chondroitin 4-sulfate + H2O	-	Homo sapiens	chondroitin + sulfate	-	?
chondroitin 4-sulfate-tetrasaccharide + H2O	only the 4-sulfated endgroup is attacked by the enzyme, sulfate is released only in presence of beta-glucuronidase, acts as exosulphatase	Homo sapiens	chondroitin 4-sulfate-tetrasaccharide + sulfate	-	?
N-acetyl-D-galactosamine 4-sulfate units + H2O	acts also on N-acetylglucosamine 4-sulfate	Homo sapiens	N-acetyl-D-galactosamine units + sulfate	-	?
p-nitrocatechol sulfate + H2O	enzymes catalyze in addition to reaction of EC 3.1.6.12 also arylsulfatase reaction , see also EC 3.1.6.1	Homo sapiens	p-nitrocatechol + sulfate	-	?

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Release 2023.1 (January 2023)