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Literature summary for 3.1.6.12 extracted from

  • McGovern, M.M.; Vine, D.T.; Haskins, M.E.; Desnick, R.J.
    Purification and properties of feline and human arylsulfatase B isozymes. Evidence for feline homodimeric and human monomeric structures (1982), J. Biol. Chem., 257, 12605-12610.
    View publication on PubMed
Search for more literature for 3.1.6.12

Activating Compound

Activating Compound Comment Organism Structure
EDTA
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
K2HPO4
-
 Felis catus
K2HPO4
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2
-
 nitrocatechol sulfate
-
 Homo sapiens
1.2
-
 nitrocatechol sulfate
-
 Felis catus
3.6
-
 nitrocatechol sulfate
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ stimulates Homo sapiens
Mn2+ stimulates Homo sapiens
Mn2+ stimulates Felis catus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
38000
-
 1 * 38000, SDS-PAGE Homo sapiens
41000
-
 2 * 41000, SDS-PAGE after suberimidate treatment Felis catus
48000
-
 gel filtration Homo sapiens
100000
-
 gel filtration Felis catus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetyl-D-galactosamine 4-sulfate units + H2O Homo sapiens acts also on N-acetylglucosamine 4-sulfate N-acetyl-D-galactosamine units + sulfate
-
 ?
N-acetyl-D-galactosamine 4-sulfate units + H2O Felis catus acts also on N-acetylglucosamine 4-sulfate N-acetyl-D-galactosamine units + sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Felis catus
-
-
-
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-
liver
-
 Felis catus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-D-galactosamine 4-sulfate units + H2O acts also on N-acetylglucosamine 4-sulfate Homo sapiens N-acetyl-D-galactosamine units + sulfate
-
 ?
N-acetyl-D-galactosamine 4-sulfate units + H2O acts also on N-acetylglucosamine 4-sulfate Felis catus N-acetyl-D-galactosamine units + sulfate
-
 ?
p-nitrocatechol sulfate + H2O enzymes catalyze in addition to reaction of EC 3.1.6.12 also arylsulfatase reaction , see also EC 3.1.6.1 Homo sapiens p-nitrocatechol + sulfate
-
 ?
p-nitrocatechol sulfate + H2O enzymes catalyze in addition to reaction of EC 3.1.6.12 also arylsulfatase reaction , see also EC 3.1.6.1 Felis catus p-nitrocatechol + sulfate
-
 ?
UDP-N-acetylgalactosamine-4-sulfate + H2O
-
 Homo sapiens UDP-N-acetylgalactosamine + sulfate
-
 ?
UDP-N-acetylgalactosamine-4-sulfate + H2O
-
 Felis catus UDP-N-acetylgalactosamine + sulfate
-
 ?

Subunits

Subunits Comment Organism
dimer
-
 Homo sapiens
dimer 2 * 41000, SDS-PAGE after suberimidate treatment Felis catus
monomer
-
 Felis catus
monomer 1 * 38000, SDS-PAGE Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
60
-
 t1/2: 30 min Homo sapiens
60
-
 20 min Homo sapiens
60
-
 20 min Felis catus
60
-
 t1/2: 68 min Felis catus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.7
-
-
 Homo sapiens
5.7
-
-
 Felis catus