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Literature summary for 3.1.6.1 extracted from

  • Van Loo, B.; Berry, R.; Boonyuen, U.; Mohamed, M.; Golicnik, M.; Hengge, A.; Hollfelder, F.
    Transition-state interactions in a promiscuous enzyme sulfate and phosphate monoester hydrolysis by Pseudomonas aeruginosa arylsulfatase (2019), Biochemistry, 58, 1363-1378 .
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Pseudomonas sp. UW4 K9NCQ5
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-fluoro-4-nitrophenyl sulfate + H2O
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Pseudomonas sp. UW4 2-fluoro-4-nitrophenol + sulfate
-
?
3,4-dimethylphenyl sulfate + H2O
-
Pseudomonas sp. UW4 3,4-dimethylphenol + sulfate
-
?
3,4-dinitrophenyl sulfate + H2O
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Pseudomonas sp. UW4 3,4-dinitrophenol + sulfate
-
?
3-bromophenyl sulfate + H2O
-
Pseudomonas sp. UW4 3-bromophenol + sulfate
-
?
3-chlorophenyl sulfate + H2O
-
Pseudomonas sp. UW4 3-chlorophenol + sulfate
-
?
3-cyanophenyl sulfate + H2O
-
Pseudomonas sp. UW4 3-cyanophenol + sulfate
-
?
3-fluoro-4-nitrophenyl sulfate + H2O
-
Pseudomonas sp. UW4 3-fluoro-4-nitrophenol + sulfate
-
?
3-nitrophenyl sulfate + H2O
-
Pseudomonas sp. UW4 3-nitrophenol + sulfate
-
?
4-chlorophenyl sulfate + H2O
-
Pseudomonas sp. UW4 4-chlorophenol + sulfate
-
?
4-fluorophenyl sulfate + H2O
-
Pseudomonas sp. UW4 4-fluorophenol + sulfate
-
?
4-nitrophenyl sulfate + H2O
-
Pseudomonas sp. UW4 4-nitrophenol + sulfate
-
?
additional information the mechanism for S-O-bridge bond fission shifts, with decreasing leaving group ability, from charge compensation via Lewis acid interactions toward direct proton donation. The transition state for enzyme-catalyzed sulfate monoester hydrolysis has a significantly more associative character compared to the uncatalyzed reaction Pseudomonas sp. UW4 ?
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