Literature summary for 3.1.5.B1 extracted from

Lee, E.J.; Seo, J.H.; Park, J.H.; Vo, T.T.L.; An, S.; Bae, S.J.; Le, H.; Lee, H.S.; Wee, H.J.; Lee, D.; Chung, Y.H.; Kim, J.A.; Jang, M.K.; Ryu, S.H.; Yu, E.; Jang, S.H.; Park, Z.Y.; Kim, K.W.
SAMHD1 acetylation enhances its deoxynucleotide triphosphohydrolase activity and promotes cancer cell proliferation (2017), Oncotarget, 8, 68517-68529 .

Search for more literature for 3.1.5.B1

Protein Variants

Protein Variants	Comment	Organism
K405R	mutant cannot be acetylated, reduced activity compared to acetylated wild-type protein. K405R mutant expressing cancer cells show reduced G1/S transition and slower proliferation compared to wildtype	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9Y3Z3	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
acetylation	SAMHD1 is acetylated at residue K405 in vitro and in vivo by acetylatransferase arrest defective protein ARD1. Acetylated SAMHD1 wildtype proteins have enhanced dNTPase activity in vitro. SAMHD1 acetylation levels are strongest during the G1 phase	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatocarcinoma cell	-	Homo sapiens	-
liver	-	Homo sapiens	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)