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Literature summary for 3.1.5.B1 extracted from

  • Gelais, C.; Kim, S.; Maksimova, V.; Buzovetsky, O.; Knecht, K.; Shepard, C.; Kim, B.; Xiong, Y.; Wu, L.
    A cyclin-binding motif in human SAMHD1 is required for its HIV-1 restriction, dNTPase activity, tetramer formation, and efficient phosphorylation (2018), J. Virol., 92, e01787 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
R451A/L453A mutation in the RXL motif, disrupts SAMHD1 tetramer formation and abolishes its dNTPase activity in vitro and in cells. The mutant fails to restrict HIV-1 infection and has reduced binding to cyclin A2 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y3Z3
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General Information

General Information Comment Organism
metabolism SAMHD1 and R451A/L453A mutant proteins are degraded by virion-associated protein Vpx from HIV-2 but are not spontaneously ubiquitinated in the absence of Vpx. Their protein levels are enhanced only when both proteasomal and autophagy degradation pathways are inhibited Homo sapiens