Protein Variants | Comment | Organism |
---|---|---|
R451A/L453A | mutation in the RXL motif, disrupts SAMHD1 tetramer formation and abolishes its dNTPase activity in vitro and in cells. The mutant fails to restrict HIV-1 infection and has reduced binding to cyclin A2 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9Y3Z3 | - |
- |
General Information | Comment | Organism |
---|---|---|
metabolism | SAMHD1 and R451A/L453A mutant proteins are degraded by virion-associated protein Vpx from HIV-2 but are not spontaneously ubiquitinated in the absence of Vpx. Their protein levels are enhanced only when both proteasomal and autophagy degradation pathways are inhibited | Homo sapiens |