Literature summary for 3.1.5.B1 extracted from

Tramentozzi, E.; Ferraro, P.; Hossain, M.; Stillman, B.; Bianchi, V.; Pontarin, G.
The dNTP triphosphohydrolase activity of SAMHD1 persists during S-phase when the enzyme is phosphorylated at T592 (2018), Cell Cycle, 17, 1102-1114 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in U2OS cell	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9Y3Z3	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	S-phase kinase CDK2-cyclin A phosphorylates SAMHD1 at residue Thr-592. Thr-592 phosphorylation occurs first at the G1/S border and is removed during mitotic exit. Thr-592 phosphorylation does not cause rapid protein degradation	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	S-phase kinase CDK2-cyclin A phosphorylates SAMHD1 at residue Thr-592. Thr-592 phosphorylation occurs first at the G1/S border and is removed during mitotic exit. Thr-592 phosphorylation does not cause rapid protein degradation. SAMHD1 influences the size of the four dNTP pools independently of its phosphorylation	Homo sapiens

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Release 2023.1 (January 2023)