Application | Comment | Organism |
---|---|---|
analysis | high-throughput screen that directly measures SAMHD1 catalytic activity, utilizing bis(4-nitrophenyl) phosphate as the substrate and Mn2+ as the activating cation | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
amrinone | IC50 value below 250 microM, Hill coefficient between 0.5 and 1.5 | Homo sapiens | |
ergotamine | IC50 value below 250 microM, Hill coefficient between 0.5 and 1.5 | Homo sapiens | |
Hexestrol | IC50 value below 250 microM, Hill coefficient between 0.5 and 1.5 | Homo sapiens | |
L-thyroxine | IC50 value below 250 microM, Hill coefficient between 0.5 and 1.5 | Homo sapiens | |
lomofungin | IC50 value below 250 microM, Hill coefficient between 0.5 and 1.5 | Homo sapiens | |
montelukast | IC50 value below 250 microM, Hill coefficient between 0.5 and 1.5 | Homo sapiens | |
retinoic acid | IC50 value below 250 microM, Hill coefficient between 0.5 and 1.5 | Homo sapiens | |
sulindac | IC50 value below 250 microM, Hill coefficient between 0.5 and 1.5 | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mn2+ | with substrate bis(4-nitrophenyl) phosphate, enzyme is able to tetramerize in presence of Mn2+ | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9Y3Z3 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
bis(4-nitrophenyl) phosphate + H2O | - |
Homo sapiens | 4-nitrophenyl phosphate + 4-nitrophenol | - |
? |