Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dNTP | both GTP and dNTP are required for tetramer activation of the enzyme. SAMHD1 activation is regulated by the concentration of dNTP | Homo sapiens | |
GTP | both GTP and dNTP are required for tetramer activation of the enzyme | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
structures of the catalytic core of SAMHD1 in complex with different combinations of GTP and dNTPs. SAMHD1 contains two activator-binding sites in the allosteric pocket. The primary activator GTP binds to one site and the substrate dNTP (dATP, dCTP, dUTP or dTTP) occupies the other. Both GTP and dNTP are required for tetramer activation of the enzyme. In the absence of substrate binding, SAMHD1 adopts an inactive dimer conformation even when complexed with GTP | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9Y3Z3 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
SAMHD1 | - |
Homo sapiens |