Protein Variants | Comment | Organism |
---|---|---|
Q320A | decrease in catalytic activity | Homo sapiens |
Q320S | decrease in catalytic activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,4-dioxo-N-[4-(4-pyridyl)phenyl]-1H-quinazoline-6-sulfonamide | reversible uncompetitive inhibitor, compound binds via a reversible mechanism to the enzyme's zinc center. Compound is not inhibitory to carbonic anhydrase II, neutral endopeptidase and angiotensin-converting enzyme | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q6IQ20 | - |
- |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0367 | - |
mutant Q320S, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2,4-dioxo-N-[4-(4-pyridyl)phenyl]-1H-quinazoline-6-sulfonamide | |
0.0462 | - |
wild-type, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2,4-dioxo-N-[4-(4-pyridyl)phenyl]-1H-quinazoline-6-sulfonamide | |
0.0892 | - |
mutant Q320A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2,4-dioxo-N-[4-(4-pyridyl)phenyl]-1H-quinazoline-6-sulfonamide |