Literature summary for 3.1.4.54 extracted from

Nagy, B.; Fedonidis, C.; Photiou, A.; Wahba, J.; Paule, C.C.; Ma, D.; Buluwela, L.; Nagy, I.
Capsaicin-sensitive primary sensory neurons in the mouse express N-acyl phosphatidylethanolamine phospholipase D (2009), Neuroscience, 161, 572-577.

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Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	required	Mus musculus
Zn2+	dependent on, NAPE-PLD belongs to the zinc metallohydrolase family of the beta-lactamase fold	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q8BH82	male C57BL/6 mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Mus musculus	-
ganglion	expression of NAPE-PLD in dorsal root ganglia	Mus musculus	-
heart	-	Mus musculus	-
additional information	neuronal tissue distribution of NAPE-PLD expression analysis, quantitative realtime PCR	Mus musculus	-
neuron	cultured primary sensory neurons	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
N-acyl phosphatidylethanolamine phospholipase D	-	Mus musculus
NAPE-PLD	-	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	capsaicin treatment overnight downregulates NAPE-PLD expression in capsaicin-sensitive cells by 70% at 0.01 mM	down

General Information

General Information	Comment	Organism
physiological function	NAPE-PLD produces various long and medium chain bioactive N-acylethanolamines, including anandamide in a Ca2+-dependent fashion. Primary sensory neurons, including the capsaicin-sensitive cells are capable of producing anandamide	Mus musculus

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Release 2023.1 (January 2023)