Activating Compound | Comment | Organism | Structure |
---|---|---|---|
1,2-dihexanoyl-glycero-3-(hexanoylamino)propylphosphonate | i.e. AHP-57, a phosphonic acid, activates 1.9fold at 1 mM | Homo sapiens | |
cardiolipin | from bovine liver, activates by 68% at 1 mM | Homo sapiens | |
methyl-1,2-dihexanoyl-glycero-3-(hexanoylamino)propylphosphonate | i.e. AHP-38, a methylphosphonate, activates 68% at 1 mM | Homo sapiens | |
methyl-1,2-dihexanoyl-glycero-3-(tetradecanoylamino)propylphosphonate | i.e. AHP-36, a methylphosphonate, activates 2fold at 1 mM | Homo sapiens | |
additional information | activator synthesis, overview | Homo sapiens | |
phosphatidylbutanol | activates 81% at 1 mM | Homo sapiens | |
phosphatidylcholine | activates 2.75fold at 1 mM | Homo sapiens | |
phosphatidylethanolamine | activates | Homo sapiens | |
phosphatidylethanolamine | activates 5.91fold at 1 mM | Homo sapiens | |
phosphatidylinositol | activates 99% at 1 mM | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
stable expression of NAPE-PLD in HEK-293 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,2-dihexanoyl-glycero-N-(3-(tetradecanoylamino)propyl)phosphoramidate | i.e. AHP-71B, 96.6% inhibition at 1 mM | Homo sapiens | |
N-(2,4-dinitrophenyl)-1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine | 1 mM, 35.6% inhibition | Homo sapiens | |
nitrocefin | - |
Homo sapiens | |
phosphatidylhexanol | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | NAPE-PLD is a zinc metallohydrolase | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acylphosphatidylethanolamine + H2O | Homo sapiens | N-acylethanolamines constitute a family of endogenous bioactive lipids that includes arachidonoylethanolamide, i.e. anandamide, palmitoylethanolamide, and oleoylethanolamide. These lipids are formed from their respective N-acylated ethanolamine phospholipid precursor by the action of a phospholipase D enzyme, NAPE-PLD. The bioactive lipids may influence, amongst others: neuroinflammation, food intake, and oocyte implantation | N-acylethanolamine + phosphatidate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q6IQ20 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,2-dihexadecyl-sn-glycerol-3-phospho-(N-palmitoyl)ethanolamine + H2O | - |
Homo sapiens | N-palmitoylethanolamine + 1,2-dihexadecyl-sn-glycerol-3-phosphate | - |
? | |
N-acylphosphatidylethanolamine + H2O | N-acylethanolamines constitute a family of endogenous bioactive lipids that includes arachidonoylethanolamide, i.e. anandamide, palmitoylethanolamide, and oleoylethanolamide. These lipids are formed from their respective N-acylated ethanolamine phospholipid precursor by the action of a phospholipase D enzyme, NAPE-PLD. The bioactive lipids may influence, amongst others: neuroinflammation, food intake, and oocyte implantation | Homo sapiens | N-acylethanolamine + phosphatidate | - |
? | |
N-palmitoyl-1,2-dilauroylphosphatidylethanolamine + H2O | - |
Homo sapiens | N-palmitoylethanolamine + 1,2-dilauroyl-sn-glycerol 3-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NAPE-PLD | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.01 | - |
pH 8.0, 37°C | Homo sapiens | 1,2-dihexanoyl-glycero-N-(3-(tetradecanoylamino)propyl)phosphoramidate |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme catalyzes a step in the biosynthesis of N-acylethanolamines, the biosynthetic route of N-acylethanolamines seems to involve at least three alternative pathways, overview | Homo sapiens |