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Literature summary for 3.1.4.54 extracted from

  • Leung, D.; Saghatelian, A.; Simon, G.M.; Cravatt, B.F.
    Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids (2006), Biochemistry, 45, 4720-4726.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.54

Organism

Organism UniProt Comment Textmining
Mus musculus Q8BH82
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-

Source Tissue

Source Tissue Comment Organism Textmining
brain
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-palmitoyl-1,2-dioleoyl-phosphatidylethanolamine + H2O
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 Mus musculus N-palmitoylethanolamine + 1,2-dioleoyl-sn-glycerol 3-phosphate
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 ?

Synonyms

Synonyms Comment Organism
NAPE-PLD
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 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Mus musculus

General Information

General Information Comment Organism
malfunction generation and characterization of mice with a targeted disruption in the NAPE-PLD gene [NAPE-PLD(-/-) mice]. Brain tissue from NAPE-PLD-(-/-) mice shows more than a 5fold reduction in the calcium-dependent conversion of N-acyl-phosphatidylethanolamines to N-acylethanolamines bearing both saturated and polyunsaturated N-acyl chains. Only the former group of N-acylethanolamines is decreased in level in NAPE-PLD(-/-) brains, and these reductions are most dramatic for N-acylethanolamines bearing very long acyl chains (above C20). Further studies identified a calcium independent phospholipase D activity in brains from NAPE-PLD(-/-) mice that accepts multiple N-acylethanolamine substrates, including the anandamide precursor C20:4 N-acylphosphatidylethanolamine Mus musculus