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Literature summary for 3.1.4.53 extracted from

  • Cao, B.; Wang, K.; Liao, J.M.; Zhou, X.; Liao, P.; Zeng, S.X.; He, M.; Chen, L.; He, Y.; Li, W.; Lu, H.
    Inactivation of oncogenic cAMP-specific phosphodiesterase 4D by miR-139-5p in response to p53 activation (2016), eLife, 5, e15978 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3',5'-cAMP + H2O Homo sapiens
-
 5'-AMP
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q08499
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
colorectal cancer cell
-
 Homo sapiens
-
H-1299 cell
-
 Homo sapiens
-
H-460 cell
-
 Homo sapiens
-
HCT-116 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cAMP + H2O
-
 Homo sapiens 5'-AMP
-
 ?

Synonyms

Synonyms Comment Organism
cAMP-specific phosphodiesterase 4D
-
 Homo sapiens
PDE4D
-
 Homo sapiens
phosphodiesterase 4D
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens p53 inactivates isoform PDE4D by inducing the expression of miR-139-5p which directly binds to the target sequence at 3'-UTR of PDE4D mRNA down