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Literature summary for 3.1.4.53 extracted from

  • Rampersad, S.; Ovens, J.; Huston, E.; Umana, M.; Wilson, L.; Netherton, S.; Lynch, M.; Baillie, G.; Houslay, M.; Maurice, D.
    Cyclic AMP phosphodiesterase 4D (PDE4D) tethers EPAC1 in a vascular endothelial cadherin (VE-Cad)-based signaling complex and controls cAMP-mediated vascular permeability (2010), J. Biol. Chem., 285, 33614-33622.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens protein-protein interactions between EPAC1 and PDE4D, peptide mapping for binding site determination. A cell-permeable variant of this peptide antagonizes EPAC1-PDE4D binding and directly alters vascular endothelial cell permeability ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
arterial endothelial cell
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 Homo sapiens
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vascular endothelial cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information protein-protein interactions between EPAC1 and PDE4D, peptide mapping for binding site determination. A cell-permeable variant of this peptide antagonizes EPAC1-PDE4D binding and directly alters vascular endothelial cell permeability Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
cyclic nucleotide phosphodiesterase 4D
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 Homo sapiens
PDE4D
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 Homo sapiens

General Information

General Information Comment Organism
metabolism PKA, EPAC1, and PDE4D differentially regulate humanarterial endothelial cell vascular endothelial cadherin-based structures, overview. Protein-protein interactions between EPAC1 and PDE4D serve to foster their integration into vascular endothelial cadherin-based complexes and allow robust local regulation of EPAC1-based stabilization of vascular endothelial cadherin-based adhesions Homo sapiens
physiological function PDE4D regulates both the activity and subcellular localization of EPAC1, mechanism for regulated EPAC1 signaling in these cells, overview Homo sapiens