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Literature summary for 3.1.4.53 extracted from

  • Zhang, L.; Murray, F.; Zahno, A.; Kanter, J.R.; Chou, D.; Suda, R.; Fenlon, M.; Rassenti, L.; Cottam, H.; Kipps, T.J.; Insel, P.A.
    Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia (2008), Proc. Natl. Acad. Sci. USA, 105, 19532-19537.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine isoform PDE7B is a drug target in chronic lymphocytic leukemia Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
BRL-50481 PDE7 inhibitor Homo sapiens
IR-202 PDE7 inhibitor Homo sapiens
IR-284 dual PDE4/PDE7 inhibitor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
peripheral blood mononuclear cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cAMP + H2O
-
 Homo sapiens 5'-AMP
-
 ?

Synonyms

Synonyms Comment Organism
cyclic nucleotide phosphodiesterase
-
 Homo sapiens
PDE7B isoform Homo sapiens
phosphodiesterase 7B isoform Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000085
-
 pH and temperature not specified in the publication Homo sapiens IR-202
0.0002
-
 pH and temperature not specified in the publication Homo sapiens BRL-50481

Expression

Organism Comment Expression
Homo sapiens 2fold increased PDE7B mRNA expression in chronic lymphocytic leukemia correlates with a 10fold higher expression of PDE7B protein and results in an increased contribution of PDE7 to total PDE activity up