Inhibitors | Comment | Organism | Structure |
---|---|---|---|
roflumilast | roflumilast is approximately 10fold more potent than rolipram | Homo sapiens | |
rolipram | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fetus | - |
Homo sapiens | - |
HFL-1 cell | - |
Homo sapiens | - |
lung fibroblast | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
PDE4 | - |
Homo sapiens |
phosphodiesterase 4 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | PDE4 inhibition together with transforming growth factor-beta1 results in augmented PGE2 production together with increased expression of COX mRNA and protein. inhibitors may attenuate fibroblast activities that can lead to fibrosis, PDE4 inhibitors may be particularly effective in the presence of transforming growth factor-beta1-induced fibroblast stimulation | Homo sapiens |