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Literature summary for 3.1.4.53 extracted from

  • Togo, S.; Liu, X.; Wang, X.; Sugiura, H.; Kamio, K.; Kawasaki, S.; Kobayashi, T.; Ertl, R.F.; Ahn, Y.; Holz, O.; Magnussen, H.; Fredriksson, K.; Skold, C.M.; Rennard, S.I.
    PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-beta1-stimulated fibroblasts (2009), Am. J. Physiol. Lung Cell Mol. Physiol., 296, L959-L969.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
roflumilast roflumilast is approximately 10fold more potent than rolipram Homo sapiens
rolipram
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fetus
-
Homo sapiens
-
HFL-1 cell
-
Homo sapiens
-
lung fibroblast
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
PDE4
-
Homo sapiens
phosphodiesterase 4
-
Homo sapiens

General Information

General Information Comment Organism
malfunction PDE4 inhibition together with transforming growth factor-beta1 results in augmented PGE2 production together with increased expression of COX mRNA and protein. inhibitors may attenuate fibroblast activities that can lead to fibrosis, PDE4 inhibitors may be particularly effective in the presence of transforming growth factor-beta1-induced fibroblast stimulation Homo sapiens