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Literature summary for 3.1.4.53 extracted from
- Development of a fission yeast-based high-throughput screen to identify chemical regulators of cAMP phosphodiesterases (2008), J. Biomol. Screen., 13, 62-71.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Schizosaccharomyces pombe | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| imperatorin | potent PFE4 inhibitor, imperatorin is significantly more active against PDE4B than PDE4A | Mus musculus |  |
| rolipram | isozyme PDE4A is only partially inhibited by 0.02 mM rolipram, whereas PDE4B is completely inhibited at this concentration | Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3',5'-cAMP + H2O | - |
Mus musculus | 5'-AMP | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| adenosine 3',5'-cyclic monophosphate PDE | - |
Mus musculus |
| cAMP-PDE | - |
Mus musculus |
| PDE4 | - |
Mus musculus |
| PDE4A | isozyme | Mus musculus |
| PDE4B | isozyme | Mus musculus |
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Release 2023.1 (January 2023)
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