Literature summary for 3.1.4.53 extracted from

Waddleton, D.; Wu, W.; Feng, Y.; Thompson, C.; Wu, M.; Zhou, Y.P.; Howard, A.; Thornberry, N.; Li, J.; Mancini, J.A.
Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing enzymes responsible for insulin secretion in INS-1 (832/13) cells and rat islets (2008), Biochem. Pharmacol., 76, 884-893.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Rattus norvegicus INS-1 832/13 cell line	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
L-826,141	PDE4-selective inhibitor	Rattus norvegicus
roflumilast	PDE4-selective inhibitor	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-
liver	-	Rattus norvegicus	-
pancreas	-	Rattus norvegicus	-
pancreatic islet	-	Rattus norvegicus	-
skeletal muscle	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3',5'-cAMP + H2O	-	Rattus norvegicus	5'-AMP	-	?

Synonyms

Synonyms	Comment	Organism
PDE4A	isozyme	Rattus norvegicus
PDE4B	isozyme	Rattus norvegicus
PDE4C	isozyme	Rattus norvegicus
PDE4D	isozyme	Rattus norvegicus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0000001	-	isozymes PDE4A, PDE4B, and PDE4D	Rattus norvegicus	roflumilast
0.0000004	-	isozymes PDE4B and PDE4D	Rattus norvegicus	L-826,141
0.0000006	-	isozyme PDE4C	Rattus norvegicus	roflumilast
0.0000013	-	isozymes PDE4C and PDE4A	Rattus norvegicus	L-826,141

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Release 2023.1 (January 2023)