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Literature summary for 3.1.4.53 extracted from

  • Huston, E.; Pooley, L.; Julien, P.; Scotland, G.; McPhee, I.; Sullivan, M.; Bolger, G.; Houslay, M.D.
    The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram (1996), J. Biol. Chem., 271, 31334-31344.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in transfected COS7 cells. The human PDE4A species, h6.1 (HSPDE4A4C), which lacks the N-terminal extension of PDE-46, is an entirely soluble species when expressed in COS7 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
rolipram competitive inhibitor of the cytosol enzyme but as a partial competitive inhibitor of the particulate enzyme. Particulate PDE-46 shows a 60fold higher affinity for rolipram than cytosolic PDE-46 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol the enzyme associated with both the soluble and particulate fractions Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
HSPDE4A4B
-
Homo sapiens
PDE-46
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000037
-
rolipram particulate enzyme Homo sapiens
0.0016
-
rolipram cytosolic enzyme Homo sapiens