Cloned (Comment) | Organism |
---|---|
expressed in transfected COS7 cells. The human PDE4A species, h6.1 (HSPDE4A4C), which lacks the N-terminal extension of PDE-46, is an entirely soluble species when expressed in COS7 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
rolipram | competitive inhibitor of the cytosol enzyme but as a partial competitive inhibitor of the particulate enzyme. Particulate PDE-46 shows a 60fold higher affinity for rolipram than cytosolic PDE-46 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | the enzyme associated with both the soluble and particulate fractions | Homo sapiens | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Synonyms | Comment | Organism |
---|---|---|
HSPDE4A4B | - |
Homo sapiens |
PDE-46 | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000037 | - |
rolipram | particulate enzyme | Homo sapiens | |
0.0016 | - |
rolipram | cytosolic enzyme | Homo sapiens |