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Literature summary for 3.1.4.53 extracted from

  • D'Angelo, M.A.; Sanquineti, S.; Reece, J.M.; Birnbaumer, L.; Torres, H.N.; Flawia, M.M.
    Identification, characterization and subcellular localization of TcPDE1, a novel cAMP-specific phosphodiesterase from Trypanosoma cruzi (2004), Biochem. J., 378, 63-72.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
-
Trypanosoma cruzi

Inhibitors

Inhibitors Comment Organism Structure
3-isobutyl-1-methylxanthine
-
Trypanosoma cruzi
dipyridamole
-
Trypanosoma cruzi
erythro-9-(2-hydroxy-3-nonyl)-adenine hydrochloride
-
Trypanosoma cruzi
papaverine
-
Trypanosoma cruzi
rolipram
-
Trypanosoma cruzi
vinpocetine
-
Trypanosoma cruzi

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0073
-
adenosine 3',5'-cyclic phosphate
-
Trypanosoma cruzi

Localization

Localization Comment Organism GeneOntology No. Textmining
flagellum
-
Trypanosoma cruzi
-
-
plasma membrane
-
Trypanosoma cruzi 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ activity was higher in the presence of Mn2+ than Mg2+ as cofactor Trypanosoma cruzi
Mn2+ activity was higher in the presence of Mn2+ than Mg2+ as cofactor Trypanosoma cruzi

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi Q6XG56
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenosine 3',5'-cyclic phosphate + H2O
-
Trypanosoma cruzi adenosine 5'-phosphate
-
?

Synonyms

Synonyms Comment Organism
cAMP-specific phosphodiesterase
-
Trypanosoma cruzi
TcPDE1
-
Trypanosoma cruzi

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.017
-
-
Trypanosoma cruzi dipyridamole
0.111
-
-
Trypanosoma cruzi papaverine
0.134
-
-
Trypanosoma cruzi vinpocetine
0.217
-
-
Trypanosoma cruzi erythro-9-(2-hydroxy-3-nonyl)-adenine hydrochloride