Literature summary for 3.1.4.53 extracted from

Cheung, Y.F.; Kan, Z.; Garrett-Engele, P.; Gall, I.; Murdoch, H.; Baillie, G.S.; Camargo, L.M.; Johnson, J.M.; Houslay, M.D.; Castle, J.C.
PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6) (2007), J. Pharmacol. Exp. Ther., 322, 600-609.

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Inhibitors

Inhibitors	Comment	Organism	Structure
cilomilast	-	Homo sapiens
cilomilast	-	Mus musculus
rolipram	-	Homo sapiens
rolipram	-	Mus musculus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0058	-	adenosine 3',5'-cyclic phosphate	-	Mus musculus
0.0058	-	cAMP	30°C	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	uneven and predominant localization	Homo sapiens	5829	-
cytosol	PDE4B5 is distributed predominantly and unevenly within the cytosol	Mus musculus	5829	-
plasma membrane	small part of enzyme is associated with the plasma membrane	Homo sapiens	5886	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
58000	-	-	Mus musculus
58000	-	x * 58000, SDS-PAGE of isoform PDE4B5	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q07343	isoform PDE4B5, variant of PDE4B with a different 5'-terminus	-
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	isoform PDE4B5 is brain-specific	Homo sapiens	-
brain	PDE4B5 is brain-specific	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3',5'-cAMP + H2O	-	Homo sapiens	5'-AMP	-	?
adenosine 3',5'-cyclic phosphate + H2O	-	Mus musculus	adenosine 5'-phosphate	-	?

Subunits

Subunits	Comment	Organism
?	x * 58000, SDS-PAGE of isoform PDE4B5	Homo sapiens
More	isoform PDE4B5 is able to bind the scaffold protein DISC1	Homo sapiens

Synonyms

Synonyms	Comment	Organism
PDE4B5	PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6	Mus musculus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000097	-	cilomilast	-	Mus musculus
0.000114	-	cilomilast	30°C	Homo sapiens
0.000324	-	rolipram	-	Mus musculus
0.00038	-	rolipram	30°C	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000114	-	-	Mus musculus	cilomilast
0.00038	-	-	Mus musculus	rolipram

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Release 2023.1 (January 2023)