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Literature summary for 3.1.4.53 extracted from

  • Charlie, N.K.; Thomure, A.M.; Schade, M.A.; Miller, K.G.
    The Dunce cAMP phosphodiesterase PDE-4 negatively regulates G alpha(s)-dependent and G alpha(s)-independent cAMP pools in the Caenorhabditis elegans synaptic signaling network (2006), Genetics, 173, 111-130.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
D448N mutation in conserved active site residue, loss of enzyme function does not affect steady-state acetylcholine release or reception Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Caenorhabditis elegans isoform PDE4 regulates both GalphaS-dependent and GalphaS-indeoendent cAMP pools in the neurons controling locomotion rate ?
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Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
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Source Tissue

Source Tissue Comment Organism Textmining
nervous system strong expression of isoform PDE4 throughout the nervous system Caenorhabditis elegans
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information isoform PDE4 regulates both GalphaS-dependent and GalphaS-indeoendent cAMP pools in the neurons controling locomotion rate Caenorhabditis elegans ?
-
 ?