Literature summary for 3.1.4.53 extracted from

Oberholzer, M.; Marti, G.; Baresic, M.; Kunz, S.; Hemphill, A.; Seebeck, T.
The Trypanosoma brucei cAMP phosphodiesterases TbrPDEB1 and TbrPDEB2: flagellar enzymes that are essential for parasite virulence (2007), FASEB J., 21, 720-731.

Search for more literature for 3.1.4.53

Application

Application	Comment	Organism
medicine	enzyme knock-down by RNAi reveals that it may be complemented by isoform PDEB1, but simultaneous ablation of PDEB1 and PDEB2 leads to cell death in bloodstream form trypanosomes. In vivo application of RNAi completely prevents infection and eliminates ongoing infections	Trypanosoma brucei
medicine	enzyme knock-down by RNAi reveals that it may be complemented by isoform PDEB2, but simultaneous ablation of PDEB1 and PDEB2 leads to cell death in bloodstream form trypanosomes. In vivo application of RNAi completely prevents infection and eliminates ongoing infections	Trypanosoma brucei
medicine	TbrPDEB1 and TbrPDEB2 are essential for virulence, making them valuable potential targets for new PDE-inhibitor based trypanocidal drugs	Trypanosoma brucei

Protein Variants

Protein Variants	Comment	Organism
additional information	enzyme knock-down by RNAi reveals that it may be complemented by isoform PDEB1, but simultaneous ablation of PDEB1 and PDEB2 leads to cell death in bloodstream form trypanosomes. In vivo application of RNAi completely prevents infection and eliminates ongoing infections	Trypanosoma brucei
additional information	enzyme knock-down by RNAi reveals that it may be complemented by isoform PDEB2, but simultaneous ablation of PDEB1 and PDEB2 leads to cell death in bloodstream form trypanosomes. In vivo application of RNAi completely prevents infection and eliminates ongoing infections	Trypanosoma brucei

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Trypanosoma brucei	5737	-
cytoplasm	TbrPDEB2 is distributed between flagellum and cytoplasm	Trypanosoma brucei	5737	-
flagellum	-	Trypanosoma brucei	-	-
flagellum	TbrPDEB2 is distributed between flagellum and cytoplasm	Trypanosoma brucei	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Trypanosoma brucei	TbrPDEB1 and TbrPDEB2 are essential for virulence, making them valuable potential targets for new PDE-inhibitor based trypanocidal drugs	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Trypanosoma brucei	-	-	-
Trypanosoma brucei	Q38F42	isoform PDEB2	-
Trypanosoma brucei	Q38F46	isoform PDEB2	-
Trypanosoma brucei	Q8WQX9	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
bloodstream form	-	Trypanosoma brucei	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	TbrPDEB1 and TbrPDEB2 are essential for virulence, making them valuable potential targets for new PDE-inhibitor based trypanocidal drugs	Trypanosoma brucei	?	-	?

Synonyms

Synonyms	Comment	Organism
PDEB1	-	Trypanosoma brucei
TbrPDEB1	-	Trypanosoma brucei
TbrPDEB2	-	Trypanosoma brucei

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Release 2023.1 (January 2023)