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Literature summary for 3.1.4.53 extracted from

  • Levallet, G.; Levallet, J.; Bouraima-Lelong, H.; Bonnamy, P.J.
    Expression of the cAMP-phosphodiesterase PDE4D isoforms and age-related changes in follicle-stimulating hormone-stimulated PDE4 activities in immature rat sertoli cells (2007), Biol. Reprod., 76, 794-803.
    View publication on PubMed
Search for more literature for 3.1.4.53

Activating Compound

Activating Compound Comment Organism Structure
follicle-stimulating hormone stimulation Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome short variant PDE4D1 is mainly particulate Rattus norvegicus
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additional information the soluble PDE4 activities are mainly related to the long PDE4D isoforms and short PDE4D1 is predominantly particulate Rattus norvegicus
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soluble long variants of PDE4D are mainly soluble Rattus norvegicus
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus almost all the PDE4D isoforms, known as the main cAMP-regulated rolipramsensitive PDE in Sertoli cells, are expressed throughout the early postpartum period, whereas only the short PDE4D isoforms (PDE4D1 and PDE4D2) are transcriptionally regulated by FSH ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Rattus norvegicus
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 isoform PDE4D, short variants PDE4D1 and PDE4D2 are transcriptionally regulated by follicle-stimulating hormone
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Source Tissue

Source Tissue Comment Organism Textmining
Sertoli cell immature cell. Almost all PDE4D variants are expressed throughout the early postpartum period with a specific increase in PDE4 activity in both soluble and particulate fraction of 20 day old Sertoli cells Rattus norvegicus
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Sertoli cell isolated from 10-, 20-, and 30-days-old rats. Specific increase in PDE4 activity in both the soluble and particulate subcellular fractions of 20-days-old Sertoli cells. Almost all the PDE4D isoforms, known as the main cAMP-regulated rolipramsensitive PDE in Sertoli cells, are expressed throughout the early postpartum period, whereas only the short PDE4D isoforms (PDE4D1 and PDE4D2) are transcriptionally regulated by FSH. The subcellular distribution and expression of PDE4D proteins are unaffected by the developmental status of the Sertoli cells. Only the expression of short PDE4D1 appears to be upregulated by FSH and only in 20-days-old Sertoli cells, which suggests phenotype-dependent differential regulation of Pde4d1 mRNA translation Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information almost all the PDE4D isoforms, known as the main cAMP-regulated rolipramsensitive PDE in Sertoli cells, are expressed throughout the early postpartum period, whereas only the short PDE4D isoforms (PDE4D1 and PDE4D2) are transcriptionally regulated by FSH Rattus norvegicus ?
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Synonyms

Synonyms Comment Organism
PDE4D
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 Rattus norvegicus