Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.4.53 extracted from

  • Baillie, G.S.; Adams, D.R.; Bhari, N.; Houslay, T.M.; Vadrevu, S.; Meng, D.; Li, X.; Dunlop, A.; Milligan, G.; Bolger, G.B.; Klussmann, E.; Houslay, M.D.
    Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of beta-arrestin using spot-immobilized peptide arrays (2007), Biochem. J., 404, 71-80.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.53

Application

Application Comment Organism
medicine interactions of PDE4D5 with both the N- and C-terminal domains of beta-arrestin are essential for beta2-adrenoceptor regulation Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli as N-terminal glutathione S-transferase-fusion protein Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens interaction of PDE4D5 with both the N- and C-domains of beta-arrestin 2 are essential for beta2-adrenoceptor regulation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isoforms PDE4D3 and PDE4D5
-
Homo sapiens Q08499
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information interaction of PDE4D5 with both the N- and C-domains of beta-arrestin 2 are essential for beta2-adrenoceptor regulation Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More isoform PDE4D interacts with beta-arrestin. Identification of a binding site in the beta-arrestin 2 N-domain for the common PDE4D catalytic unit and two regions in the beta-arrestin 2 C domain that confer specificity for PDE4D5 binding. Reduced interaction of PDE4D5 with beta-arrestin mutants R26A, K18A, or T20A. R286, D291, and L215-H220 of beta-arrestin are important for binding PDE4D5, but not for PDE4D3. Interactions of PDE4D5 with both the N- and C-terminal domains of beta-arrestin are essential for beta2-adrenoceptor regulation Homo sapiens

Synonyms

Synonyms Comment Organism
PDE4D5
-
 Homo sapiens