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Literature summary for 3.1.4.53 extracted from

  • Alonso, G.D.; Schoijet, A.C.; Torres, H.N.; Flawia, M.M.
    TcPDE4, a novel membrane-associated cAMP-specific phosphodiesterase from Trypanosoma cruzi (2006), Mol. Biochem. Parasitol., 145, 40-49.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Trypanosoma cruzi

Inhibitors

Inhibitors Comment Organism Structure
3-isobutyl-1-methylxanthine
-
Trypanosoma cruzi
dipyridamole
-
Trypanosoma cruzi
EDTA
-
Trypanosoma cruzi
etazolate IC50: 1.3 mM Trypanosoma cruzi
papaverine
-
Trypanosoma cruzi
rolipram IC50: 10.46 mM Trypanosoma cruzi
trequinsin
-
Trypanosoma cruzi
zaprinast
-
Trypanosoma cruzi

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02
-
adenosine 3',5'-cyclic phosphate
-
Trypanosoma cruzi

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Trypanosoma cruzi 16020
-
membrane accociated Trypanosoma cruzi 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Trypanosoma cruzi
Mn2+ less efficient than Mg2+ Trypanosoma cruzi

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
-
-
-
Trypanosoma cruzi Q4ZHU6
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cAMP + H2O
-
Trypanosoma cruzi 5'-AMP
-
?
adenosine 3',5'-cyclic phosphate + H2O the enzyme is specific fpr cAMP Trypanosoma cruzi adenosine 5'-phosphate
-
?
additional information no activity with cGMP Trypanosoma cruzi ?
-
?

Synonyms

Synonyms Comment Organism
cAMP-specific phosphodiesterase
-
Trypanosoma cruzi
TcPDE4
-
Trypanosoma cruzi

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000146
-
-
Trypanosoma cruzi dipyridamole
0.0013
-
-
Trypanosoma cruzi etazolate
0.01046
-
-
Trypanosoma cruzi rolipram
0.01288
-
-
Trypanosoma cruzi papaverine
0.1262
-
-
Trypanosoma cruzi 3-isobutyl-1-methylxanthine
0.728
-
-
Trypanosoma cruzi zaprinast
1.3
-
IC50: 1.3 mM Trypanosoma cruzi etazolate
1.958
-
-
Trypanosoma cruzi trequinsin
10.46
-
IC50: 10.46 mM Trypanosoma cruzi rolipram