Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Trypanosoma cruzi |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-isobutyl-1-methylxanthine | - |
Trypanosoma cruzi | |
dipyridamole | - |
Trypanosoma cruzi | |
EDTA | - |
Trypanosoma cruzi | |
etazolate | IC50: 1.3 mM | Trypanosoma cruzi | |
papaverine | - |
Trypanosoma cruzi | |
rolipram | IC50: 10.46 mM | Trypanosoma cruzi | |
trequinsin | - |
Trypanosoma cruzi | |
zaprinast | - |
Trypanosoma cruzi |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.02 | - |
adenosine 3',5'-cyclic phosphate | - |
Trypanosoma cruzi |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Trypanosoma cruzi | 16020 | - |
membrane | accociated | Trypanosoma cruzi | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Trypanosoma cruzi | |
Mn2+ | less efficient than Mg2+ | Trypanosoma cruzi |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma cruzi | - |
- |
- |
Trypanosoma cruzi | Q4ZHU6 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cAMP + H2O | - |
Trypanosoma cruzi | 5'-AMP | - |
? | |
adenosine 3',5'-cyclic phosphate + H2O | the enzyme is specific fpr cAMP | Trypanosoma cruzi | adenosine 5'-phosphate | - |
? | |
additional information | no activity with cGMP | Trypanosoma cruzi | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cAMP-specific phosphodiesterase | - |
Trypanosoma cruzi |
TcPDE4 | - |
Trypanosoma cruzi |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000146 | - |
- |
Trypanosoma cruzi | dipyridamole | |
0.0013 | - |
- |
Trypanosoma cruzi | etazolate | |
0.01046 | - |
- |
Trypanosoma cruzi | rolipram | |
0.01288 | - |
- |
Trypanosoma cruzi | papaverine | |
0.1262 | - |
- |
Trypanosoma cruzi | 3-isobutyl-1-methylxanthine | |
0.728 | - |
- |
Trypanosoma cruzi | zaprinast | |
1.3 | - |
IC50: 1.3 mM | Trypanosoma cruzi | etazolate | |
1.958 | - |
- |
Trypanosoma cruzi | trequinsin | |
10.46 | - |
IC50: 10.46 mM | Trypanosoma cruzi | rolipram |