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Literature summary for 3.1.4.53 extracted from

  • Han, P.; Sonati, P.; Rubin, C.; Michaeli, T.
    PDE7A1, a cAMP-specific phosphodiesterase, inhibits cAMP-dependent protein kinase by a direct interaction with C (2006), J. Biol. Chem., 281, 15050-15057.
    View publication on PubMed
Search for more literature for 3.1.4.53

Localization

Localization Comment Organism GeneOntology No. Textmining
centrosome colocalization of isoform PDE7A1 with protein kinase II in the golgi-centrosome region Mus musculus 5813
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Golgi apparatus colocalization of isoform PDE7A1 with protein kinase II in the golgi-centrosome region Mus musculus 5794
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3',5'-cAMP + H2O Mus musculus PDE7A1 possesses a non-catalytic activity that can contribute to the termination of cAMP signals via direct inhibition of C subunit of cAMP-dependent protein kinase 5'-AMP
-
 ?
additional information Mus musculus PDE7A1 possesses a non-catalytic activity that can contribute to the termination of cAMP signals via direct inhibition of the C subunit of the cAMP-dependent kinase ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus
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 isoform PDE7A1
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Source Tissue

Source Tissue Comment Organism Textmining
beta-TC3 cell
-
 Mus musculus
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beta-TC3 cell PDE7A1 co-localizes with PKA II in the Golgi centrosome region Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cAMP + H2O
-
 Mus musculus 5'-AMP
-
 ?
3',5'-cAMP + H2O PDE7A1 possesses a non-catalytic activity that can contribute to the termination of cAMP signals via direct inhibition of C subunit of cAMP-dependent protein kinase Mus musculus 5'-AMP
-
 ?
cAMP + H2O isoform PDE7A1 possesses a non-catalytic activity that can contribute to the termination of cAMP signals via direct inhibition of C subunit of cAMP-dependent protein kinase Mus musculus 5'-AMP
-
 ?
additional information PDE7A1 possesses a non-catalytic activity that can contribute to the termination of cAMP signals via direct inhibition of the C subunit of the cAMP-dependent kinase Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
More isoform PDE7A1 associates with the dissociated C subunit of cAMP dependent protein kinase, but does not bind tetrameric protein kinase holoenzyme. Binding of protein kinase C subunit inhibits kinase activity in vitro, the N-terminal repeat region f PDE7A1 is sufficient for inhibition Mus musculus

Synonyms

Synonyms Comment Organism
cAMP-specific phosphodiesterase
-
 Saccharomyces cerevisiae
PDE7A1
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 Mus musculus
PDE7A1
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 Saccharomyces cerevisiae