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Literature summary for 3.1.4.53 extracted from

  • Johner, A.; Kunz, S.; Linder, M.; Shakur, Y.; Seebeck, T.
    Cyclic nucleotide specific phosphodiesterases of Leishmania major (2006), BMC Microbiol., 6, 25.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.53

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Leishmania major

Inhibitors

Inhibitors Comment Organism Structure
(2E)-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-2,3,6,7-tetrahydro-4H-pyrimido[6,1-a]isoquinolin-4-one
-
 Leishmania major
dipyridamole
-
 Leishmania major
etazolate
-
 Leishmania major
Milrinone
-
 Leishmania major
papaverine
-
 Leishmania major
rolipram
-
 Leishmania major

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00099
-
 3',5'-cAMP
-
 Leishmania major
0.00698
-
 3',5'-cAMP
-
 Leishmania major

Organism

Organism UniProt Comment Textmining
Leishmania major Q6S996
-
-
Leishmania major Q6S997
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cAMP + H2O LmjPDEB1 is completely cAMP-specific Leishmania major 5'-AMP
-
 ?
3',5'-cAMP + H2O LmjPDEB2 is completely cAMP-specific Leishmania major 5'-AMP
-
 ?

Synonyms

Synonyms Comment Organism
class I phosphodiesterase PDEB1
-
 Leishmania major
class I phosphodiesterase PDEB2
-
 Leishmania major
LmjPDEB1
-
 Leishmania major
LmjPDEB2
-
 Leishmania major