Literature summary for 3.1.4.52 extracted from

Jimenez-Fernandez, A.; Lopez-Sanchez, A.; Calero, P.; Govantes, F.
The c-di-GMP phosphodiesterase BifA regulates biofilm development in Pseudomonas putida (2015), Environ. Microbiol. Rep., 7, 78-84 .

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Organism

Organism	UniProt	Comment	Textmining
Pseudomonas putida	-	-	-
Pseudomonas putida KT2442	-	-	-

Synonyms

Synonyms	Comment	Organism
BifA	-	Pseudomonas putida

General Information

General Information	Comment	Organism
physiological function	a bifA mutant displays increased biofilm and pellicle formation, cell aggregation in liquid medium and decreased starvation-induced biofilm dispersal relative to the wild type. The mutation does not affect swarming motility. The hyperadherent phenotype of the mutant correlates with a general increase in cyclic diguanylate levels, Congo Red-binding exopolysaccharide production and transcription of the adhesin-encoding lapA gene. Integrity of the EAL motif and a modified GGDEF motif are crucial for BifA activity. c-Di-GMP depletion by overexpression of a heterologous cyclic di-GMP phosphodiesterase in the mutant restores wild-type biofilm dispersal and lapA expression	Pseudomonas putida

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Release 2023.1 (January 2023)