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Literature summary for 3.1.4.52 extracted from

  • Tamayo, R.; Schild, S.; Pratt, J.T.; Camilli, A.
    Role of cyclic di-GMP during el tor biotype Vibrio cholerae infection: characterization of the in vivo-induced cyclic di-GMP phosphodiesterase CdpA (2008), Infect. Immun., 76, 1617-1627.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.52

Activating Compound

Activating Compound Comment Organism Structure
additional information cyclic-di-GMP phosphodiesterase activity of CdpA is regulated by its inactive degenerate GGDEF domain Vibrio cholerae serotype O1

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cyclic di-3',5'-guanylate + H2O Vibrio cholerae serotype O1
-
 5'-phosphoguanylyl(3'-5')guanosine
-
 ?

Organism

Organism UniProt Comment Textmining
Vibrio cholerae serotype O1
-
 biotype el tor
-
Vibrio cholerae serotype O1
-
 El Tor biotype strain C6709
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cyclic di-3',5'-guanylate + H2O
-
 Vibrio cholerae serotype O1 5'-phosphoguanylyl(3'-5')guanosine
-
 ?

Synonyms

Synonyms Comment Organism
c-di-GMP phosphodiesterase
-
 Vibrio cholerae serotype O1
CdpA
-
 Vibrio cholerae serotype O1
CdpA CdpA possesses PDE activity Vibrio cholerae serotype O1
cyclic di-GMP phosphodiesterase
-
 Vibrio cholerae serotype O1
PDE
-
 Vibrio cholerae serotype O1

Expression

Organism Comment Expression
Vibrio cholerae serotype O1 cdpA is expressed during in vitro growth in a biofilm but is not expressed in vivo until the late stage of infection, after colonization has occurred, cdpA expression is not regulated by cyclic-di-GMP concentration additional information
Vibrio cholerae serotype O1 cdpA is expressed during in vitro growth in a biofilm but is not expressed in vivo until the late stage of infection, after colonization has occurred up

General Information

General Information Comment Organism
physiological function CdpA inhibits biofilm formation but has no effect on colonization of the infant mouse small intestine Vibrio cholerae serotype O1