Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.4.52 extracted from

  • Gotoh, H.; Zhang, Y.; Dallo, S.F.; Hong, S.; Kasaraneni, N.; Weitao, T.
    Pseudomonas aeruginosa, under DNA replication inhibition, tends to form biofilms via Arr (2008), Res. Microbiol., 159, 294-302.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information mutation of Arr leads to suppression of induction of biofilm formation Pseudomonas aeruginosa

Inhibitors

Inhibitors Comment Organism Structure
GTP inhibition of the phosphodiesterase, reduction of tobramycin biofilm stimulation, and suppression of biofilm response, overview Pseudomonas aeruginosa
additional information inhibition of the enzyme leads to suppression of induction of biofilm formation Pseudomonas aeruginosa
Nalidixic acid reduction of tobramycin biofilm stimulation and suppression of biofilm response, overview Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cyclic di-3',5'-guanylate + H2O Pseudomonas aeruginosa degradation 5'-phosphoguanylyl(3'-5')guanosine
-
?
additional information Pseudomonas aeruginosa Arr is required for induction of biofilms under DNA replication stress by a mechanism of stimulated adhesion of planktonic filaments having impaired DNA replication, the induction is suppressed by either inhibition or mutation of the c-di-GMP phosphodiesterase, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
gene arr
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cyclic di-3',5'-guanylate + H2O
-
Pseudomonas aeruginosa 5'-phosphoguanylyl(3'-5')guanosine
-
?
cyclic di-3',5'-guanylate + H2O degradation Pseudomonas aeruginosa 5'-phosphoguanylyl(3'-5')guanosine
-
?
additional information Arr is required for induction of biofilms under DNA replication stress by a mechanism of stimulated adhesion of planktonic filaments having impaired DNA replication, the induction is suppressed by either inhibition or mutation of the c-di-GMP phosphodiesterase, overview Pseudomonas aeruginosa ?
-
?

Synonyms

Synonyms Comment Organism
Arr
-
Pseudomonas aeruginosa
c-di-GMP phosphodiesterase
-
Pseudomonas aeruginosa