Activating Compound | Comment | Organism | Structure |
---|---|---|---|
KCl | highest catalytic activity in presence of 25 mM KCl | Vibrio cholerae serotype O1 |
Protein Variants | Comment | Organism |
---|---|---|
E170A | mutation in metal binding site, loss of activity | Vibrio cholerae serotype O1 |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | strong | Vibrio cholerae serotype O1 | |
Zn2+ | strong | Vibrio cholerae serotype O1 |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00006 | - |
cyclic di-3',5'-guanylate | 23°C, pH 7.0 | Vibrio cholerae serotype O1 |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | or Mn2+, required, with Mg2+ being more efficient. Enzyme activity increases with with increasing Mg2+ concentration up to 25 mM MgCl2 | Vibrio cholerae serotype O1 | |
Mn2+ | or Mg2+, required, with Mg2+ being more efficient | Vibrio cholerae serotype O1 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Vibrio cholerae serotype O1 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cyclic di-3',5'-guanylate + H2O | - |
Vibrio cholerae serotype O1 | 5'-phosphoguanylyl(3'-5')guanosine | - |
? | |
additional information | no substrate: cyclic guanosine monophosphate | Vibrio cholerae serotype O1 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
VieA | - |
Vibrio cholerae serotype O1 |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
23 | 30 | - |
Vibrio cholerae serotype O1 |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
52 | - |
loss of activity above | Vibrio cholerae serotype O1 |
65 | - |
no residual activity | Vibrio cholerae serotype O1 |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
- |
Vibrio cholerae serotype O1 |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5 | 9 | no significant changes in reaction rates within this range | Vibrio cholerae serotype O1 |