Literature summary for 3.1.4.50 extracted from

Masuda, S.; Fujishima, Y.; Maeda, N.; Tsugawa-Shimizu, Y.; Nakamura, Y.; Tanaka, Y.; Obata, Y.; Fukuda, S.; Nagao, H.; Kita, S.; Nishizawa, H.; Shimomura, I.
Impact of glycosylphosphatidylinositol-specific phospholipase D on hepatic diacylglycerol accumulation, steatosis, and insulin resistance in diet-induced obesity (2019), Am. J. Physiol. Endocrinol. Metab., 316, E239-E250 .

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Application

Application	Comment	Organism
medicine	the hepatic mRNA level and circulating concentration of GPI-PLD are significantly augmented in diabetic mice	Rattus norvegicus
medicine	the hepatic mRNA level and circulating concentration of GPI-PLD are significantly augmented in diabetic mice	Homo sapiens
medicine	the hepatic mRNA level and circulating concentration of GPI-PLD are significantly augmented in diabetic mice	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P80108	-	-
Mus musculus	Q7TNZ4	-	-
Rattus norvegicus	Q8R2H5	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatocyte	primary hepatocyte	Rattus norvegicus	-
liver	highest expression level	Mus musculus	-
serum	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
Gpld1	-	Rattus norvegicus
Gpld1	-	Homo sapiens
Gpld1	-	Mus musculus

Expression

Organism	Comment	Expression
Rattus norvegicus	the hepatic mRNA level and circulating concentration of GPI-PLD are significantly augmented in diabetic mice	up
Homo sapiens	the hepatic mRNA level and circulating concentration of GPI-PLD are significantly augmented in diabetic mice	up
Mus musculus	the hepatic mRNA level and circulating concentration of GPI-PLD are significantly augmented in diabetic mice	up

General Information

General Information	Comment	Organism
physiological function	GPI-PLD directly regulates intracellular diacylglycerol content in primary hepatocytes. Serum GPI-PLD levels are strongly and independently associated with serum alanine transaminase and triglyceride levels in male subjects with metabolic syndrome	Rattus norvegicus
physiological function	mice lacking GPI-PLD exhibit glucose intolerance and hepatic steatosis under high-fat and high-sucrose diet. Diacylglycerol content is significantly decreased, and protein kinase PKCepsilon activity is suppressed in the livers of knockout mice	Mus musculus
physiological function	serum GPI-PLD level is strongly and independently associated with serum alanine transaminase and triglyceride levels in human male subjects	Homo sapiens

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Release 2023.1 (January 2023)