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Literature summary for 3.1.4.50 extracted from
- Down-regulation of glycosylphosphatidylinositol-specific phospholipase D induced by lipopolysaccharide and oxidative stress in the murine monocyte-macrophage cell line RAW 264.7 (2001), Infect. Immun., 69, 3214-3223.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | enzyme activity is over 75% reduced in systemic inflammatory response syndrome, downregulation of enzyme could play an important role in the control of proinflammatory responses | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | downregulation of enzyme could play an important role in the control of proinflammatory responses | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| RAW-264.7 cell | macrophage cell line | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | downregulation of enzyme could play an important role in the control of proinflammatory responses | Mus musculus | ? | - |
? | |
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