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Literature summary for 3.1.4.46 extracted from

  • Cao, M.D.; Doepkens, M.; Krishnamachary, B.; Vesuna, F.; Gadiya, M.M.; Loenning, P.E.; Bhujwalla, Z.M.; Gribbestad, I.S.; Glunde, K.
    Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer (2012), NMR Biomed., 25, 1033-1042.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glycerophosphocholine + H2O Homo sapiens
-
 choline + glycerol-3-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8WTR4
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell the isozyme GDPD5 is significantly overexpressed in highly malignant estrogen receptor negative compared to weakly malignant estrogen receptor positive human breast cancer cells and breast tumors from patients, GDPD5 expression in tumors and correlation to choline containing metabolite levels, overview Homo sapiens
-
MCF-12A cell nonmalignant human mammary epithelial cells Homo sapiens
-
MCF-7 cell estrogen-sensitive weakly metastatic human breast cancer cells Homo sapiens
-
MDA-MB-231 cell estrogen-independent highly metastatic human breast cancer cells Homo sapiens
-
additional information isozyme GDPD5 is ubiquitously expressed in human tissues Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycerophosphocholine + H2O
-
 Homo sapiens choline + glycerol-3-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
GDPD5
-
 Homo sapiens
glycerophosphodiester phosphodiesterase domain containing 5
-
 Homo sapiens
GPC-PDE
-
 Homo sapiens

General Information

General Information Comment Organism
evolution the human glycerophosphodiester phosphodiesterase domain (GDPD) containing family consists of 5 isozymes, GDPD1-5 Homo sapiens
malfunction the enzyme encoded by glycerophosphodiester phosphodiesterase domain containing 5 is associated with breast cancer malignancy Homo sapiens
metabolism the isozyme GDPD5 is a glycerophosphodiester phosphodiesterase that likely participates in regulating choline phospholipid metabolism in breast cancer, which possibly occurs in cooperation with choline kinase alpha and phosphatidylcholine-specific phospholipase D1 Homo sapiens